Seroprevalence and detection of primary infection by cytomegalovirus with IgG avidity test during the first quarter of pregnancy

• Published in: Salud pública de México Vol. 56; no. 6; pp. 619 - 624
• Main Authors: González-García, Conne L, Reyes-Méndez, Miguel A, Ortega-Pierres, Luz E, Rodríguez-Sánchez, Adriana P, Sandoval-Guido, Verónica, Sereno-Coló, José A
• Format: Journal Article
• Language: Spanish
• Published: Mexico 01.11.2014
• Subjects: Adolescent; Adult; Antibodies, Viral - blood; Antibody Affinity; Cross-Sectional Studies; Cytomegalovirus - immunology; Cytomegalovirus Infections - epidemiology; Female; Hospitals, General - statistics & numerical data; Humans; Immunoglobulin G - blood; Mexico - epidemiology; Middle Aged; Pregnancy; Pregnancy Complications, Infectious - epidemiology; Pregnancy Trimester, First; Seroepidemiologic Studies
• ISSN: 1606-7916

To determine the seroprevalence and detection of primary infection by cytomegalovirus (CMV) with immunoglobulin G (IgG) avidity test during the first quarter of pregnancy in the General Hospital in Morelia, Michoacan. A total of 177 patients were studied employing a modified Elisa test using a chemiluminescent microparticle immunoassay (CMIA) for the detection of CMV antibodies (IgG and immunoglobulin M [IgM]), and IgG avidity. 90.4% were positive for IgG, and of these, 2.3% were also reactive for IgM, and in this group the IgG avidity test reported low avidity for 1.1% and higher avidity in the same percentage. 9.6% were seronegative. Similarity was found with published studies in Mexico. Health professionals should know the clinical algorithms for diagnosis and proper management of CMV infection using the IgG avidity test.