Antibody-mediated rejection: challenge of the treatment in kidney transplantated patients

• Published in: Orvosi hetilap Vol. 159; no. 46; p. 1913
• Main Authors: Nemes, Balázs, P Szabó, Réka, Bidiga, László, Kalmár Nagy, Károly, Illésy, Lóránt, Szilvási, Anikó
• Format: Journal Article
• Language: Hungarian
• Published: Hungary 01.11.2018
• Subjects: antibody; plasmapheresis; veseátültetés; kidney transplant; antitest; plazmaferézis; rejection; rejekció; rituximab
• ISSN: 0030-6002
• DOI: 10.1556/650.2018.31295

Antibody-mediated rejection (ABMR) is one of the factors affecting the long-term graft survival after kidney transplantation (KT). Two kidney transplant centres (University of Debrecen and University of Pécs) followed up their data of cadaveric KTs that had been performed between 2013 and 2017, and reviewed the literature. There were 454 KTs in the mentioned period, 18 cases (4%) were recognised as ABMRs. Biopsy has been performed in all cases. 22% were primary, and 78% retransplanted patients. The average age was 51.2 ± 6 years. ABMR occurred 15.4 ± 22.1 months after KT. Histology showed C4d positivity in 39% of the cases. The treatment was steroid bolus + intravenous immunoglobulin (IVIG) + plasma exchange (PE) in 16 cases, rituximab was additionally given in 5 cases. 47.4% of the patients are alive with a functioning graft, four (21%) died, and 31% of the patients had a graft loss due to ABMR. ABMR is a dangerous complication after KT. Diagnostic criteria has been unclear for years. Gold standard is the histology, however, accelerated ABMR may occur even in C4d negative cases. The exposed group includes young, retransplanted patients, having a preformed donor-specific antibody (DSA), and receiving a graft from an EC donor. The occurrence of de novo DSA and the kinetics of mean fluorescence intensity (MFI) of existing ones can be a signal for the risk of an ABMR. The effectiveness of rituximab is not proven, there is a lack of long-term controlled trials for new drugs. Our results of over 40% recovery is an extensively good result. Orv Hetil. 2018; 159(46): 1913-1929.