Spontaneous remission of HCV infection after autologous stem cell transplantation in a 58-year-old man

We report about a 58-year-old man with a chronic and treatment-naive hepatitis C virus (HCV) infection of genotype 1b, who had undergone autologous stem cell transplantation twice due to multiple myeloma. Subsequently, a high-level viremic reactivation of an occult hepatitis B virus (HBV) infection...

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Published inDer Internist (Berlin) Vol. 58; no. 6; pp. 621 - 625
Main Authors Reinhardt, L, Eiffert, H, Wulf, G, Ströbel, P, Bremer, S C B, Amanzada, A, Ellenrieder, V, Neesse, A
Format Journal Article
LanguageGerman
Published Germany 01.06.2017
Subjects
Antiviral Agents - therapeutic use
Hepacivirus
Hepatitis B - drug therapy
Hepatitis B - immunology
Hepatitis B virus - physiology
Hepatitis C - therapy
Humans
Male
Middle Aged
Multiple Myeloma - therapy
Remission, Spontaneous
Stem Cell Transplantation
Tenofovir - therapeutic use
Virus Activation
Tenofovir
Seroconversion, reverse
Coinfection
Hepatitis B virus
Multiple myeloma
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Summary:We report about a 58-year-old man with a chronic and treatment-naive hepatitis C virus (HCV) infection of genotype 1b, who had undergone autologous stem cell transplantation twice due to multiple myeloma. Subsequently, a high-level viremic reactivation of an occult hepatitis B virus (HBV) infection and also a reverse seroconversion was observed. Furthermore, a sustained spontaneous remission of HCV infection was seen. Antiviral therapy of HBV infection was initiated with tenofovir. Seven months after therapy initiation, the patient acquired an "anti-HBc-only" status. Antiviral therapy with tenofovir is still continued. The patient is in a good clinical condition.
Bibliography:ObjectType-Case Study-2
SourceType-Scholarly Journals-1
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ISSN:1432-1289
DOI:10.1007/s00108-017-0206-3