Immunopathogenesis of systemic lupus erythematosus

Insights into the immunopathogenesis of systemic lupus erythematosus (SLE) help to understand the complex disease patterns and to develop new treatment strategies. The disease manifestations essentially result from autoantibodies, immune complexes and cytokines. Particularly the propensity towards d...

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Bibliographic Details
Published inZeitschrift für Rheumatologie Vol. 83; no. 1; pp. 68 - 76
Main Authors Aringer, Martin, Finzel, Stephanie, Voll, Reinhard E
Format Journal Article
LanguageGerman
Published Germany 01.02.2024
Subjects
Autoantibodies
B-Lymphocytes
Cytokines
Humans
Lupus Erythematosus, Systemic - drug therapy
Antibodies
Plasma cells
Interferon
Immune complexes
BLyS/BAFF
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Summary:Insights into the immunopathogenesis of systemic lupus erythematosus (SLE) help to understand the complex disease patterns and to develop new treatment strategies. The disease manifestations essentially result from autoantibodies, immune complexes and cytokines. Particularly the propensity towards developing various autoantibodies is central to the disease itself; autoantibody specificities lead to highly variable organ manifestations. This review article delineates the clinically relevant state of knowledge on SLE pathogenesis, with the goal to establish a model useful for clinical practice, which also helps to classify the novel therapeutic approaches.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Review-1
ISSN:1435-1250
DOI:10.1007/s00393-022-01214-4