Biological effect of nutritional recovery on serum concentrations of inflammation cytokines in the malnourished child

• Published in: Investigación clínica Vol. 56; no. 4; p. 356
• Main Authors: Pereira, Nayda, Echeverría-Velasquez, Miriam, Nuñez-Gonzalez, José R, Molano, Nelly, Atencio, Teresa, Amel, Anilsa, Gil, Luis, Álvarez de Mon, Melchor
• Format: Journal Article
• Language: Spanish
• Published: Venezuela 01.12.2015
• ISSN: 0535-5133

Children with severe malnutrition have a dysfunction of the immune response that can significantly increase morbidity and mortality from infections. The aim of this investigation was to evaluate the effect of nutritional recovery in serum measurements of inflammatory cytokines; such as interleukin 12 (IL-12), interleukin 17 (IL-17), interferon gamma (IFN-γ) and tumor necrosis factor alpha (TNF-α). In a prospective and longitudinal study, 24 severe malnourished children aged between 1 and 2 years-old, who were part of a program of nutritional recovery, were selected based on clinical and anthropometric criteria. Serum measurements of cytokines were determined before and after dietary treatment, using the technique of sandwich Enzyme-Linked ImmunoSorbent Assay (ELISA). For comparisons, Student’s t test was used, considered p <0.05 as statistically significant. A difference was observed in the concentrations of IL-12, IL-17, IFN-γ and TNF-α before and after treatment (p <0.05), which suggests that malnutrition provokes an inflammatory state and two months of intensive nutritional support, not only promotes the clinical recovery of severe malnourished children, but also the recovery of the immune response with regard to the production of soluble mediators, such as cytokines.