Brain iron accumulation in a blood donor family with restless legs syndrome

The pathophysiology of restless legs syndrome (RLS) is complex. Secondary RLS with iron deficiency -which suggests disturbed iron homeostasis- remains to be elucidated. We report the findings from a unique blood donor family with RLS. Three blood donors family members were diagnosed with RLS defined...

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Published inRevista de neurologiá Vol. 68; no. 3; pp. 107 - 110
Main Authors Lillo-Triguero, L, Del Castillo, A, Guzman de Villoria, J, Moran-Jimenez, M J, Guillem, A, Peraita-Adrados, R
Format Journal Article
LanguageSpanish
English
Published Spain 01.02.2019
Subjects
Adult
Aged
Anemia, Iron-Deficiency - complications
Basal Ganglia - chemistry
Blood Donors
Brain - diagnostic imaging
Brain - metabolism
Brain Chemistry
Cerebellar Nuclei - chemistry
Erythropoiesis
Female
Ferritins - blood
Hemoglobins - analysis
Humans
Iron - analysis
Iron - metabolism
Iron - pharmacokinetics
Magnetic Resonance Imaging
Male
Middle Aged
Neuroimaging
Pedigree
Polysomnography
Red Nucleus - chemistry
Restless Legs Syndrome - genetics
Restless Legs Syndrome - metabolism
Smoking
Substantia Nigra - chemistry
Transferrin - analysis
Vitamin B 12 Deficiency - complications
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Summary:The pathophysiology of restless legs syndrome (RLS) is complex. Secondary RLS with iron deficiency -which suggests disturbed iron homeostasis- remains to be elucidated. We report the findings from a unique blood donor family with RLS. Three blood donors family members were diagnosed with RLS defined by the International RLS Study Group and without history of neurologic diseases and RLS symptoms in the last 3-5 years (range of blood donation: 10-40 years). The neurological examination and electromyographies were normal. A polisomnography showed disturbed nocturnal sleep with a reduction in sleep efficiency and an increased periodic limbs movement index. The cranial MRI showed brain iron deposits in basal ganglia, substantia nigra, red nuclei and dentate nuclei. Phenotypic and genotypic studies rule out genetic haemochromatosis or iron overload. The abnormal iron accumulation in the basal ganglia indicated a complex iron metabolism disorder of the central nervous system. Further studies are warranted to confirm our findings and its role in the pathophysiology of RLS.
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ISSN:1576-6578
DOI:10.33588/rn.6803.2018466