Autoimmune hepatitis/primary sclerosing cholangitis overlap syndrome in adults: report of three cases

Overlap syndromes are cases of liver diseases that share clinical, serological, histological and radiological criteria of autoimmune hepatitis (AIH), primary biliary cirrhosis (PBC) or primary sclerosing cholangitis (PSC). No definitions have been fully established and therefore there is no solid ev...

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Published inGastroenterología y hepatología Vol. 35; no. 4; p. 254
Main Authors Santos, Oscar Mauricio, Muñoz Ortiz, Edison, Pérez, Camilo, Restrepo, Juan Carlos
Format Journal Article
LanguageSpanish
Published Spain 01.04.2012
Subjects
Adult
Cholangitis, Sclerosing - diagnosis
Female
Hepatitis, Autoimmune - diagnosis
Humans
Male
Middle Aged
Syndrome
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Summary:Overlap syndromes are cases of liver diseases that share clinical, serological, histological and radiological criteria of autoimmune hepatitis (AIH), primary biliary cirrhosis (PBC) or primary sclerosing cholangitis (PSC). No definitions have been fully established and therefore there is no solid evidence on the diagnosis and treatment. This article presents the cases of three adult patients with overlapping features of AIH and PSC. Orthotopic liver transplantation was considered the best therapeutic alternative due to advanced disease progression in one patient, while medical treatment was provided in the remaining two patients.
ISSN:0210-5705
DOI:10.1016/j.gastrohep.2011.12.003