RALP: comparison of the oncological and functional outcomes of the intrafascial and the interfascial approaches

• Published in: Progrès en urologie (Paris) Vol. 25; no. 1; p. 54
• Main Authors: Al-Mamari, S A, Quintens, H, Mentine, N, Burté, C, Rouyer, N, Jacob, G, Amiel, J
• Format: Journal Article
• Language: French
• Published: France 01.01.2015
• Subjects: Aged; Follow-Up Studies; Humans; Incontinence Pads - utilization; Male; Middle Aged; Penile Erection; Prostate-Specific Antigen - blood; Prostatectomy - methods; Prostatic Neoplasms - blood; Prostatic Neoplasms - complications; Prostatic Neoplasms - surgery; Robotic Surgical Procedures - methods; Urinary Incontinence - etiology; Marges chirurgicales; Urinary incontinence; Dysfonction érectile; Incontinence urinaire; Biochemical failure; Récidive biochimique; Surgical margins; Erectile dysfunction; Chirurgie robotique; Robotic Assisted Laparoscopic radical Prostatectomy (RALP); Prostatectomie totale
• ISSN: 1166-7087
• DOI: 10.1016/j.purol.2014.08.237

Due to its technical ease and greater precision Robotic Assisted Laparoscopic radical Prostatectomy (RALP) allows a better preservation of the neurovascular bundles, thereby improving functional outcomes. The intrafascial dissection has been proposed to allow a more complete preservation of these bundles. However, this technique harbors a high rate of positive surgical margins, justifying another trend: the interfascial approach. To date, there are still few publications directly comparing these 2 techniques and our study is the first to offer a 2-year follow-up. Our study focused on a two-hundred patients population divided into two consecutive groups. All the patients were continent preoperatively and had a satisfactory IIEF5 score: (1) Group 1 consisted of 100 patients who underwent RALP with the intrafascial approach. They had a mean age of 60.3 years (45-70). The majority of cancers were of the low or moderate risk group of d'Amico. The mean PSA was 7.43ng/ml. Seventy-five patients had a pT2, 24 a pT3 and one patient had a pT4. (2) Group 2 included 100 patients who underwent RALP with the interfascial technique. Patients had a mean age of 61.6±5.96 years (45-72), and their cancers were mostly of the low or moderate risk groups of d'Amico. The mean PSA was 6.3ng/ml. Seventy-four patients had a pT2, 22 a pT3a, and 4 had a pT3b. All patients were evaluated after one and two years of follow-up. Rates of positive surgical margins were 45% and 19% respectively for groups 1 and 2 (P<0.0001). The rates of biochemical failure (PSA>0.2ng/ml) at 2 years were 10% and 3%, respectively for groups 1 and 2 (P=0.0447). At 2 years, 2 patients in group 1 and one patient in group 2 were using 2 or more urinary pads. Erection with or without oral medication was maintained in 65 (65%) and 31 (31%) patients respectively for groups 1 and 2 at one year. At 2 years 86 and 65 patients were having spontaneous erection, respectively in groups 1 and 2 (P=0.0006). In addition, 65 and 55 patients were also capable of sexual penetration, respectively in groups 1 and 2 (P=0.0045). The intrafascial approach exposed to a very high rate of positive surgical margins while offering only a little benefit in the erectile function preservation at 2 years compared to the interfascial variant. In our series, we did not notice any significant difference between the two techniques concerning the urinary continence. 5.