Basal cell carcinoma with matrical differentiation

Basal cell carcinoma with matrical differentiation is a very rare variant of basal cell carcinoma. To our knowledge, less than 30 cases have been reported. This tumor is composed of basaloid lobules showing a differentiation toward the pilar matrix cells. Recently, it has been demonstrated that beta...

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Bibliographic Details
Published inAnnales de pathologie Vol. 35; no. 2; p. 159
Main Authors Goldman-Lévy, Gabrielle, Frouin, Eric, Soubeyran, Isabelle, Maury, Géraldine, Guillot, Bernard, Costes, Valérie
Format Journal Article
LanguageFrench
Published France 01.04.2015
Subjects
Aged
Carcinoma, Basal Cell - pathology
Female
Hand
Humans
Skin Neoplasms - pathology
Carcinome basocellulaire à différenciation matricielle
Bêta-caténine
Basal cell carcinoma
Beta-catenin
Shadow cells
Cellules fantômes
Matrical differentiation
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Summary:Basal cell carcinoma with matrical differentiation is a very rare variant of basal cell carcinoma. To our knowledge, less than 30 cases have been reported. This tumor is composed of basaloid lobules showing a differentiation toward the pilar matrix cells. Recently, it has been demonstrated that beta-catenin would interfer with physiopathogenesis of matrical tumors, in particular pilomatricomas, but also basal cell carcinomas with matrical differentiation. This is a new case, with immunohistochemical and molecular analysis of beta-catenin, in order to explain its histogenesis.
ISSN:0242-6498
DOI:10.1016/j.annpat.2015.01.001