Results of the treatment in selected infertile patients with high density of endometrial NK cells CD56+ and CD16+ Second part

• Published in: Ceská gynekologie Vol. 83; no. 2; p. 115
• Main Authors: Ulčová-Gallová, Z, Pešek, M, Haschová, M, Chaloupka, P, Mukenšnabl, P, Cibulka, J, Lošan, P, Bibková, K, Mičanová, Z
• Format: Journal Article
• Language: Czech
• Published: Czech Republic 2018
• Subjects: Adult; CD56 Antigen - immunology; Chorionic Gonadotropin; Endometrium - pathology; Female; Fertilization in Vitro; Humans; Immunomodulation; Infertility, Female - drug therapy; Killer Cells, Natural - immunology; Pregnancy; Receptors, IgG - immunology; natural killer cells endometrium; treatment; immunoglobulins; infertility
• ISSN: 1210-7832

This statements follows the first part of our publication entitled Screening of endometrial NK cells in selected infertile patients (First part - Methods and current results), where we dealt with methodology and endometrial findings of the natural killer cells CD16+ and CD56+. These cells are among the most important in preimplantaion, and in implantation period, in early pregnancy too, but can also negatively influence above mentioned processes. We focused on the immunomodulatory treatment with intramuscular immunoglobulins in 21 infertile patients with a high density of endometrial NK cells CD16+ and CD56+. Original work-prospective study. Genetics-Pilsen. From the originally investigated 57 women aged 25-41 (average 34) years with their history of 3-9 abortions, we target on a high selective subgroup of 21 infertile patients with pathological density of endometrial NK cells CD56+ and CD16+. Twelve patients underwent immunomodulatory treatment with intramuscular immunoglobulin in time of positive HCG and went on the therapeutic scheme, nine infertile women continued with IVF-ET but did not achieve HCG positivity despite of initial treatment with immunoglobulins. Of the 12 treated patients, seven of them gave a birth to healthy babies, as to the next five pregnancies - one was extrauterine pregnancy, one genetically defective fetus, three pregnancies go on successfully.Nine women from the IVF program did not get pregnat. Immunomodulatory treatment with immunoglobulins also influences endometrial NK cells CD56+ and CD16+ associating with an overproduction of embryocytoxic cytokines. Treatment of our patients with the pathological endometrial density of NK cells must be solved strictly individually.