Endothelial dysfunction in ischemic strokes in diabetes mellitus

The progression of an ischemic stroke concerns the activation of endothelial cells especially in patients with diabetes mellitus type 2. The aim of our study was to evaluate the endothelial dysfunction in patients with acute ischemic stroke with diabetes mellitus type 2. We measured the plasma activ...

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Bibliographic Details
Published inZhurnal nevrologii i psikhiatrii imeni S.S. Korsakova Vol. 111; no. 12 Pt 2; p. 28
Main Authors Shchepankevich, L A, Vostrikova, E V, Pilipenko, P I, Iarmoshchuk, A V, Akhundova, L E, Miasnikova, N G, Fedorova, K O, Kononova, E A
Format Journal Article
LanguageRussian
Published Russia (Federation) 2011
Subjects
Diabetes Mellitus, Type 2 - blood
Diabetes Mellitus, Type 2 - complications
Diabetes Mellitus, Type 2 - physiopathology
Endothelium, Vascular - physiopathology
Female
Humans
Male
Middle Aged
Stroke - blood
Stroke - pathology
Stroke - physiopathology
von Willebrand Factor - analysis
von Willebrand Factor - immunology
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Summary:The progression of an ischemic stroke concerns the activation of endothelial cells especially in patients with diabetes mellitus type 2. The aim of our study was to evaluate the endothelial dysfunction in patients with acute ischemic stroke with diabetes mellitus type 2. We measured the plasma activities of von Willebrand factor (vWf) as endothelial markers. The plasma vWf activities were significantly elevated in the index group compared to patients with ischemic stroke and arterial hypertension and controls. The correlation of the neurologic deficit severity to day 21 with the activity of endothelial dysfunction was revealed as well.
ISSN:1997-7298