Primary bone lymphoma with multicentric involvement

• Published in: Medicina (Buenos Aires) Vol. 72; no. 5; pp. 428 - 430
• Main Authors: Graziadio, Marcelo, Medina, Natalia, Amato, Marcelo, Ardaiz, María Del Carmen, Ilutovich, Santiago, Torino, Marcelo
• Format: Journal Article
• Language: Spanish
• Published: Argentina 2012
• Subjects: Antibodies, Monoclonal, Murine-Derived - therapeutic use; Antineoplastic Combined Chemotherapy Protocols - therapeutic use; Bone Neoplasms - drug therapy; Bone Neoplasms - pathology; Cyclophosphamide - therapeutic use; Doxorubicin - therapeutic use; Female; Femoral Neoplasms - drug therapy; Femoral Neoplasms - pathology; Humans; Lymphoma, Large B-Cell, Diffuse - drug therapy; Lymphoma, Large B-Cell, Diffuse - pathology; Middle Aged; Neoplasms, Multiple Primary - drug therapy; Neoplasms, Multiple Primary - pathology; Prednisone - therapeutic use; Rare Diseases - drug therapy; Rare Diseases - pathology; Skull Neoplasms - drug therapy; Skull Neoplasms - pathology; Sternum - pathology; Vincristine - therapeutic use
• ISSN: 0025-7680

Primary bone lymphoma is a rare disease, which usually has a different presentation and evolution than lymphomas of other locations. We are presenting a case of primary bone lymphoma of rapid growth, in cranial and sternal locations. In its evolution, once the excision of the primary lesion of the skull was performed, the patient presented new lesions of rapid growth at the skull and femur level, and progression of pre-sternal lesion. With large B-cell diffuse non-Hodgkin lymphoma pathology, the patient initiated R-CHOPP (cyclophosphamide, doxorubicin, vincristine, prednisone and rituximab) with rapid reduction of all lesions without evidence of progression after the six cycles.