Macrophage migration inhibitory factor in obese and non obese women with polycystic ovary syndrome

• Published in: Endocrinologia y nutricion Vol. 62; no. 1; p. 31
• Main Authors: Mejia-Montilla, Jorly, Álvarez-Mon, Melchor, Reyna-Villasmil, Eduardo, Torres-Cepeda, Duly, Santos-Bolívar, Joel, Reyna-Villasmil, Nadia, Suarez-Torres, Ismael, Bravo-Henríquez, Alfonso
• Format: Journal Article
• Language: English; Spanish
• Published: Spain 01.01.2015
• Subjects: Adult; Androstenedione - blood; Blood Glucose; Body Mass Index; Female; Follicle Stimulating Hormone - blood; Humans; Insulin - blood; Intramolecular Oxidoreductases - blood; Luteinizing Hormone - blood; Macrophage Migration-Inhibitory Factors - blood; Obesity - blood; Ovary - diagnostic imaging; Polycystic Ovary Syndrome - blood; Sex Hormone-Binding Globulin - analysis; Testosterone - blood; Young Adult; Macrophage migration inhibitory factor; Obesidad; Obesity; Polycystic ovary syndrome; Factor inhibidor de la migración de macrófagos; Síndrome de ovarios poliquísticos
• ISSN: 1579-2021
• DOI: 10.1016/j.endonu.2014.09.005

To measure macrophage migration inhibitory factor (MIF) concentrations in obese and non-obese women diagnosed with polycystic ovary syndrome (PCOS). Women diagnosed with PCOS and age-matched healthy controls with regular menses and normal ovaries on ultrasound examination were selected and divided into 4 groups (group A, PCOS and obese; group B, PCOS and non-obese; group C, obese controls; and group D, non-obese controls) based on body mass index (obese >30 kg/m2 and non-obese <25 kg/m2). Luteinizing hormone, follicle-stimulating hormone, androstenedione, testosterone, sex hormone-binding globulin, serum glucose, insulin and MIF levels were measured. Obese and non-obese women with PCOS had higher luteinizing hormone, follicle-stimulating hormone, androstenedione, testosterone, and insulin levels as compared to the obese and non-obese control groups, respectively (P < .0001). Women with PCOS had significantly higher MIF levels (group A, 48.6 ± 9.9 mg/ml; group B, 35.2 ± 6.0 ng/ml) as compared to controls (group C, 13.5 ± 6.0 ng/ml; group D, 12.0 ± 4.3 ng/dl; P < .0001). A weak, positive and significant correlation was seen between fasting blood glucose and insulin levels in women with PCOS (P < .05). Significant differences exist in plasma MIF levels between obese and non-obese women with and without PCOS.