Chronic idiopathic thrombocytopenia outcome during pregnancy (62 cases)

• Published in: La revue de medecine interne Vol. 33; no. 8; pp. 426 - 432
• Main Authors: Debouverie, O, Roblot, P, Roy-Péaud, F, Boinot, C, Pierre, F, Pourrat, O
• Format: Journal Article
• Language: French
• Published: France 01.08.2012
• Subjects: Adolescent; Adult; Chronic Disease; Cohort Studies; Disease Progression; Female; Humans; Infant, Newborn; Infant, Newborn, Diseases - diagnosis; Infant, Newborn, Diseases - epidemiology; Infant, Newborn, Diseases - etiology; Middle Aged; Pregnancy; Pregnancy Complications, Hematologic - diagnosis; Pregnancy Complications, Hematologic - epidemiology; Prognosis; Thrombocytopenia - complications; Thrombocytopenia - diagnosis; Thrombocytopenia - epidemiology; Young Adult
• ISSN: 1768-3122
• DOI: 10.1016/j.revmed.2012.04.013

The aim of this study was to assess the platelet count outcome during a pregnancy occurring in a series of 62 women followed for a chronic idiopathic thrombocytopenia. We studied the medical files of women who had a previous history of chronic idiopathic thrombocytopenia persistently below 150G/L for at least 1 year, and who became pregnant over a 14-year period. Sixty-two pregnancies (including 41 in women suffering from an immune thrombocytopenic purpura according to updated definition criteria) which occurred in 50 women, were analysed. At the beginning of the pregnancy, platelet count was above 150G/L in 16% of the cases and lower than 50G/L in 8%. Platelets decreased by more than 25% for 55% of the pregnancies, remained stable during pregnancy in 33% and improved in 12%. Platelet count remained above 50G/L in 70% of the pregnancies and higher than 100G/L in 27%. Mean nadir was 84G/L at 31 weeks of gestation. A treatment was started in 40% of pregnancies, among them 64% of the cases during the last month only in order to allow locoregional anaesthesia at delivery. Platelet count was below 150G/L at delivery in 82% of the women (116±56G/L). No bleeding occurred in 83% of the pregnancies. Neonatal mean platelet count was 225±87G/L, thrombocytopenia occurred in 17% of the babies (platelet count below 150G/L), without any serious bleeding. Pregnancy worsens chronic idiopathic thrombocytopenia outcome in half of the cases, most of the time without any haemorrhagic complications.