Nutritional and functional state of patients with chronic obstructive pulmonary disease: effects of oral nutritional supplementation (OFOS study)

• Published in: Nutrición hospitalaria : organo oficial de la Sociedad Española de Nutrición Parenteral y Enteral Vol. 34; no. 4; pp. 776 - 783
• Main Authors: Benito Martínez, Maria Del Pilar, La Serna Infantes, Jorge Estanislao, Guarro Riba, Marta, Morera Inglès, Mireia, Camere Colarossi, Diego Marco, Camere Torrealva, Marco Antonio
• Format: Journal Article
• Language: Spanish
• Published: Spain 28.07.2017
• Subjects: Administration, Oral; Adolescent; Adult; Aged; Aged, 80 and over; Dietary Supplements; Female; Humans; Male; Malnutrition - complications; Malnutrition - prevention & control; Middle Aged; Nutritional Support - methods; Prospective Studies; Pulmonary Disease, Chronic Obstructive - physiopathology; Pulmonary Disease, Chronic Obstructive - therapy; Weight Loss; Young Adult
• ISSN: 1699-5198
• DOI: 10.20960/nh.748

Weight loss and malnutrition are associated with a worse prognosis of chronic obstructive pulmonary disease (COPD). The main objective of the OFOS study was to assess the efficacy and tolerability of a new nutritional oral formula in adults with COPD with weight loss or malnutrition. Prospective, single-centre, randomized, open-label and controlled trial conducted in Lima (Peru). A total of 99 outpatients of both sexes were included (control [GC]: 49; supplement [GS]: 50), aged from 18 to 80 years old, who had been diagnosed with COPD and that suffered from malnutrition or involuntary weight loss during the last months. Nutritional, functional and quality of life (QoL) variables were evaluated during a three-month intervention. At three months, there was an increase of body mass index (BMI) and fat free mass index (FFMI) significantly higher in the GS: IMC 5.3% vs 2.9%, p < 0.001; FFMI 3.2% vs 1.9%, p = 0.019. The GS showed a reduction of cases with BMI < 21 kg/m2 equivalent to 69% vs33% in the GC (p = 0.004). Functional variables showed a favourable improvement trend in GS, being significant for the hand-grip test in the subgroup of patients with low FFMI (p = 0.001). All QoL studied variables significantly improved in both groups (p < 0.001). Oral supplementation with a complete, polymeric and normocaloric new nutritional formula for three months was well tolerated and effective for the nutritional support of patients diagnosed with COPD with weight loss or malnutrition.