50th anniversary of cisplatin

We have just celebrated the 50th anniversary of cisplatin cytotoxic potential discovery. It is time to take stock… and it seems mainly positive. This drug, that revolutionized the treatment of many cancer types, continues to be the most widely prescribed chemotherapy. Despite significant toxicities,...

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Bibliographic Details
Published inBulletin du cancer Vol. 104; no. 2; p. 167
Main Authors Rancoule, Chloé, Guy, Jean-Baptiste, Vallard, Alexis, Ben Mrad, Majed, Rehailia, Amel, Magné, Nicolas
Format Journal Article
LanguageFrench
Published France 01.02.2017
Subjects
Antineoplastic Agents - adverse effects
Antineoplastic Agents - chemistry
Antineoplastic Agents - history
Antineoplastic Agents - pharmacology
Cisplatin - adverse effects
Cisplatin - chemistry
Cisplatin - history
Cisplatin - pharmacology
DNA Adducts
Drug Resistance, Neoplasm
History, 20th Century
History, 21st Century
Resistance
Carboplatine
Chemotherapy
Oxaliplatin
Cisplatine
Carboplatin
Toxicités
Oxaliplatine
Chimiothérapie
Toxicities
Résistances
Cisplatin
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Summary:We have just celebrated the 50th anniversary of cisplatin cytotoxic potential discovery. It is time to take stock… and it seems mainly positive. This drug, that revolutionized the treatment of many cancer types, continues to be the most widely prescribed chemotherapy. Despite significant toxicities, resistance mechanisms associated with treatment failures, and unresolved questions about its mechanism of action, the use of this cytotoxic agent remains unwavering. The interest concerning this "old" invincible drug has not yet abated. Indeed many research axes are in the news. New platinum salts agents are tested, new cisplatin formulations are developed to target tumor cells more efficiently, and new combinations are established to increase the cytotoxic potency of cisplatin or overcome the resistance mechanisms.
ISSN:1769-6917
DOI:10.1016/j.bulcan.2016.11.011