Transformation of myelodysplastic syndrome to acute lymphoblastic leukemia: 2 new cases

Myelodysplastic syndromes (MDS) are clonal disorders of hematopoietic stem cells, with a variable risk of transformation to acute myeloid leukemia. Progression into acute lymphoblastic leukemia (ALL) is an extremely rare event, with very few cases published in children. In this report, we describe t...

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Published inAnales de pediatría (Barcelona, Spain : 2003) Vol. 78; no. 6; pp. 393 - 397
Main Authors Guillén, M, Madero, L, Parra, L, Hernández, C, Herrero, B, Carceller, F, Lassaletta, A, Sevilla, J
Format Journal Article
LanguageSpanish
Published Spain 01.06.2013
Subjects
Acute Disease
Cell Transformation, Neoplastic
Child, Preschool
Female
Humans
Male
Myelodysplastic Syndromes - complications
Myelodysplastic Syndromes - pathology
Precursor Cell Lymphoblastic Leukemia-Lymphoma - etiology
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Summary:Myelodysplastic syndromes (MDS) are clonal disorders of hematopoietic stem cells, with a variable risk of transformation to acute myeloid leukemia. Progression into acute lymphoblastic leukemia (ALL) is an extremely rare event, with very few cases published in children. In this report, we describe two cases of myelodysplastic syndromes that progressed to ALL. Moreover, we review previously reported cases of MDS transformation to acute lymphoblastic leukemia in the pediatric population whose prognosis seems to be similar to that for adults.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Review-3
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ObjectType-Case Study-5
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ObjectType-Report-4
ISSN:1695-9531
DOI:10.1016/j.anpedi.2012.10.003