The big challenge of SARS-CoV-2 latency: testes as reservoir

In the efforts to explain COVID-19 pathophysiology, studies are being carried out on the correspondence between the expression of SARS-CoV-2 cell receptors and viral sequences. ACE2, CD147 and TMPRSS2 receptors expression could indicate poorly explored potential infection targets. For the genomic an...

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Published inGaceta médica de México Vol. 156; no. 4; pp. 328 - 333
Main Authors López-Romero, Ricardo, Nambo-Lucio, María de Jesús, Salcedo-Carrillo, Emmanuel, Hernández-Cueto, María de Los Ángeles, Salcedo-Vargas, Mauricio
Format Journal Article
LanguageEnglish
Spanish
Published Mexico 2020
Subjects
Angiotensin-Converting Enzyme 2
Basigin - genetics
Betacoronavirus - isolation & purification
Coronavirus Infections - physiopathology
Coronavirus Infections - virology
COVID-19
Gene Expression Regulation
Humans
Male
Pandemics
Peptidyl-Dipeptidase A - genetics
Pneumonia, Viral - physiopathology
Pneumonia, Viral - virology
SARS-CoV-2
Serine Endopeptidases - genetics
Testis - virology
Virus Latency
COVID-19
Virus ARN
SARS-CoV-2 cell receptors
SARS
RNA virus
Receptores celulares de SARS-CoV-2
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Summary:In the efforts to explain COVID-19 pathophysiology, studies are being carried out on the correspondence between the expression of SARS-CoV-2 cell receptors and viral sequences. ACE2, CD147 and TMPRSS2 receptors expression could indicate poorly explored potential infection targets. For the genomic analysis of SARS-CoV-2 receptors, using BioGPS information was decided, which is a portal that centralizes genetic annotation resources, in combination with that of The Human Protein Atlas, the largest portal of human transcriptome and proteome data. We also reviewed the most recent articles on the subject. RNA and viral receptor proteins expression was observed in numerous anatomical sites, which partially coincides with the information reported in the literature. High expression in testicular cells markedly stood out, and it would be therefore important ruling out whether this anatomical site is a SARS-CoV-2 reservoir; otherwise, germ cell damage, as it is observed in infections with other RNA viruses, should be determined.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
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ISSN:0016-3813
DOI:10.24875/GMM.20000295