Usefulness of serum amylase and lipase as predictors of the severity of post-endoscopic retrograde cholangiopancreatography pancreatitis

Post-ERCP pancreatitis (PEP) is the most common complication of Post-endoscopic retrograde cholangiopancreatography. to demonstrate whether serum amylase and lipase values correlate with the presence and severity of PEP. We conducted a retrospective, observational and analytical study of patients wh...

Full description

Saved in:
Bibliographic Details
Published inCirugia y cirujanos Vol. 88; no. 4; p. 428
Main Authors Martínez-Segundo, Uriel, Pinto-Angulo, Víctor M, García-Álvarez, Javier, Cruz-Reyes, Juan M, Briceño-Sáenz, Giuseppe
Format Journal Article
LanguageEnglish
Spanish
Published Mexico 2020
Subjects
Adult
Amylases - blood
Cholangiopancreatography, Endoscopic Retrograde - adverse effects
Clinical Enzyme Tests - methods
Epidemiologic Methods
Female
Humans
Lipase - blood
Male
Middle Aged
Pancreatitis - diagnosis
Pancreatitis - etiology
Sensitivity and Specificity
Severity of Illness Index
Statistics, Nonparametric
Lipasa
Endoscopic retrograde cholangiopancreatography
Amylase
Colangiopancreatografía retrógrada endoscópica
Pancreatitis
ERCP
PEP
PPCPRE
Lipase
Amilasa
CPRE
Online AccessGet more information

Cover

More Information
Summary:Post-ERCP pancreatitis (PEP) is the most common complication of Post-endoscopic retrograde cholangiopancreatography. to demonstrate whether serum amylase and lipase values correlate with the presence and severity of PEP. We conducted a retrospective, observational and analytical study of patients who underwent ERCP, those who developed pancreatitis were classified by severity according to the 2012 revised Atlanta criteria and their serum enzyme levels were analyzed. We used ROC (Receiver Operating Characteristics) curves to know the best enzyme cutoff points and analyzed their diagnostic yields. Chi-square, t-distribution and Mann-Whitney U test were used in the variable analysis and it was considered statistically significant when p < 0.05. A total 621 patients, 54 presented pancreatitis. For moderately severe and severe forms: lipase level of 1500 U/L had an area under the curve (AUC) = 0.827, 95% CI (0.67-0.98), sensitivity = 72.7%, specificity = 86%, negative predictive value = 92.5%, p < 0.05. Amylase level of 920 U/L presented AUC = 0.65, 95% CI (0.43-0.86), sensitivity = 63%, specificity = 67%, p > 0.05. Serum lipase shows correlation with the presence and severity of PEP. Amylase shows no significant correlation with PEP.
ISSN:2444-054X
DOI:10.24875/CIRU.20001691