Extensive mesenteric ischemia related to naratriptan overuse associated with grapefruit juice absorption

We reported the case of a 61-year-old woman, who has been hospitalized in ICU because of an extensive mesenteric ischaemia, involving the small bowel, secondary to a naratriptan overuse. This mesenteric ischaemia was complicated by multiple organ failure and was responsible for extensive small bowel...

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Published inAnnales françaises d'anesthésie et de réanimation Vol. 31; no. 5; pp. 472 - 474
Main Authors Gergaud, S, Lermite, E, Butel, F, Soltner, C, Lasocki, S
Format Journal Article
LanguageFrench
Published France 01.05.2012
Subjects
Abdominal Pain - etiology
Citrus paradisi
Colectomy
Electrocardiography
Female
Food-Drug Interactions
Humans
Intestines - surgery
Ischemia - chemically induced
Ischemia - surgery
Middle Aged
Multiple Organ Failure - complications
Piperidines - adverse effects
Serotonin Agents - adverse effects
Shock - drug therapy
Shock - etiology
Splanchnic Circulation - physiology
Tryptamines - adverse effects
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Summary:We reported the case of a 61-year-old woman, who has been hospitalized in ICU because of an extensive mesenteric ischaemia, involving the small bowel, secondary to a naratriptan overuse. This mesenteric ischaemia was complicated by multiple organ failure and was responsible for extensive small bowel resection and left colectomy. A concomitant abundant absorption of grapefruit juice, a well-known P450 inhibitor, may have enhanced this naratriptan toxicity. This case underscore that an abdominal pain occurring in the context of headache treatment may be related to a mesenteric ischaemia.
Bibliography:ObjectType-Case Study-2
SourceType-Scholarly Journals-1
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ISSN:1769-6623
DOI:10.1016/j.annfar.2012.01.022