Interdisciplinary AWMF guideline for the treatment of primary antibody deficiencies

Currently, management of antibody deficient patients differs significantly among caregivers. Evidence and consensus based (S3) guidelines for the treatment of primary antibody deficiencies were developed to improve the management of these patients. Based on a thorough analysis of current evidence (s...

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Published inKlinische Padiatrie Vol. 224; no. 6; p. 404
Main Authors Krudewig, J, Baumann, U, Bernuth von, H, Borte, M, Burkhard-Meier, U, Dueckers, G, Foerster-Waldl, E, Franke, K, Habermehl, P, Hönig, M, Kern, W, Kösters, K, Kugel, K, Lehrnbecher, T, Liese, J, Marks, R, Müller, G A, Müller, R, Nadal, D, Peter, H-H, Pfeiffer-Kascha, D, Schneider, M, Sitter, H, Späth, P, Wahn, V, Welte, T, Niehues, T
Format Journal Article
LanguageGerman
Published Germany 01.10.2012
Subjects
Adult
Anti-Infective Agents - therapeutic use
Child, Preschool
Combined Modality Therapy
Cooperative Behavior
Evidence-Based Medicine
Humans
Immunization, Passive
Immunologic Deficiency Syndromes - therapy
Interdisciplinary Communication
Physical Therapy Modalities
Quality Improvement
Randomized Controlled Trials as Topic
Vaccination
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Summary:Currently, management of antibody deficient patients differs significantly among caregivers. Evidence and consensus based (S3) guidelines for the treatment of primary antibody deficiencies were developed to improve the management of these patients. Based on a thorough analysis of current evidence (systematic literature search in PubMed; deadline November 2011) 14 recommendations were finalized during a consensus meeting in Frankfurt in November 2011 using structured consensus methods (nominal group technique). Experts were nominated by their scientific societies/patient initiatives (Tab. 1). The guidelines focus on indication, practical issues and monitoring of immunoglobulin replacement therapy as well as on different routes of administration. Furthermore recommendations regarding supportive measures such as antiinfective therapy, vaccinations and physiotherapy are given. Combining literature evidence and experience of caregivers within this evidence and consensus based guidelines offers the chance to improve the quality of care for anti-body deficient patients.
ISSN:1439-3824
DOI:10.1055/s-0032-1323837