Tick-borne encefalitis - pathogenesis and -therapeutic approaches

Tick-borne encephalitis (TBE) is a major public health threat in large areas of Central and Eastern Europe and in Russia. This review summarizes the current data on the interactions between the TBE virus and the host, with a particular focus on the mechanisms of neuronal injury, immune response and...

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Bibliographic Details
Published inEpidemiologie, mikrobiologie, imunologie Vol. 64; no. 4; p. 204
Main Author Růžek, D
Format Journal Article
LanguageCzech
Published Czech Republic 01.10.2015
Subjects
Animals
Central Nervous System - immunology
Central Nervous System - pathology
Central Nervous System - virology
Encephalitis Viruses, Tick-Borne - genetics
Encephalitis Viruses, Tick-Borne - pathogenicity
Encephalitis Viruses, Tick-Borne - physiology
Encephalitis, Tick-Borne - immunology
Encephalitis, Tick-Borne - pathology
Encephalitis, Tick-Borne - therapy
Humans
Ticks - virology
tick-borne encephalitis virus - tick-borne encephalitis - antiviral therapy - pathogenesis
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Summary:Tick-borne encephalitis (TBE) is a major public health threat in large areas of Central and Eastern Europe and in Russia. This review summarizes the current data on the interactions between the TBE virus and the host, with a particular focus on the mechanisms of neuronal injury, immune response and immunopathology in the central nervous system (CNS), and factors that determine the course and outcome of TBE. Novel trends of experimental therapy of TBE are discussed. Combining small molecule inhibitors targeting viral replication with immunomodulatury agents might be a way to maximize viral clearance and minimize immunopathology in the CNS during TBE.
ISSN:1210-7913