Low-affinity Fcγ receptor IIa gene polymorphism and dengue bleeding disorder

The pathophysiological changes that determine the severity of dengue are still not well known, therefore it is important to study the probable relationship with the host genetic. We analyzed the possible association between the FcγRIIa polymorphism and clinical signs in individuals who suffered deng...

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Bibliographic Details
Published inEnfermedades infecciosas y microbiologia clinica Vol. 30; no. 10; p. 621
Main Authors García, Gissel, González, Daniel, Sánchez, Lizet, Pérez, Ana B, Sierra, Beatriz, Guzmán, María G
Format Journal Article
LanguageSpanish
Published Spain 01.12.2012
Subjects
Adult
Aged
Aged, 80 and over
Cuba - epidemiology
Disease Outbreaks
Female
Genetic Predisposition to Disease
Genotype
Humans
Male
Middle Aged
Pleural Effusion - etiology
Polymorphism, Single Nucleotide
Receptors, IgG - genetics
Retrospective Studies
Severe Dengue - blood
Severe Dengue - complications
Severe Dengue - epidemiology
Severe Dengue - genetics
Thrombocytopenia - etiology
Young Adult
Cuba
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Summary:The pathophysiological changes that determine the severity of dengue are still not well known, therefore it is important to study the probable relationship with the host genetic. We analyzed the possible association between the FcγRIIa polymorphism and clinical signs in individuals who suffered dengue infection in 2006, using contingency tables. We found that bleeding was significantly associated to FcγRIIa H/H131 genotype (80%). Our results suggest that in clinical dengue infection the bleeding could be associated to FcγRIIa H/H131 genotype.
ISSN:1578-1852
DOI:10.1016/j.eimc.2012.05.011