Rapid decline of kidney function in diabetic patients in Lomé (Togo)

• Published in: Néphrologie & thérapeutique Vol. 18; no. 7; pp. 643 - 649
• Main Authors: Tsevi, Yawovi Mawufemo, Kodjo, Kossi, Balaka, Abago, Amede, Daniel Amah, Apeti, Sodjehoun, Motte, Kokou, Nemi, Komi Dzidzonu, Djagadou, Kodjo Agbeko, Moukaila, Abdou Razak, Djibril, Mohaman Awalou
• Format: Journal Article
• Language: English; French
• Published: France 01.12.2022
• Subjects: Adolescent; Adult; Aged; Aged, 80 and over; Creatinine; Cross-Sectional Studies; Diabetes Mellitus, Type 2 - complications; Diabetic Nephropathies - complications; Glomerular Filtration Rate; Humans; Kidney; Middle Aged; Renal Insufficiency, Chronic - complications; Risk Factors; Young Adult; Lomé (Togo); Nephronic slope; Risque cardiovasculaire; Risque rénal; Pente néphronique; Cardiovascular risk; Diabète; Diabetes; Renal risk
• ISSN: 1872-9177
• DOI: 10.1016/j.nephro.2022.03.007

To determine the hospital frequency of diabetic patients with a rapid decline in their renal function, to look for the associated factors. Descriptive and analytical cross-sectional study carried out over 12 months (May 1, 2019 to April 31, 2020). Were included all patients aged 18 and over, having achieved at least 3 creatinine during the previous 2 years but spaced at least 6 months apart and having an eGFR calculated from their last creatinine greater than 30 mL/min by the formula of CDK-EPI. We evaluated the eGFR by the CDK-EPI formula using the calculator developed by the Poitiers University Hospital and the Inserm unit of the Francophone Diabetes Society. A total of 80 patients medical files were retained. The rapid decline in renal function was found in 28 patients, either a frequency of 35%. The sex ratio M/F was 1.5. The mean age was 62.93 years (range 18-85 years). Hypertension was the most common comorbidity (92.5%). The very high cardiovascular risk was predominant in 82.5% of cases. The very high renal risk was found in 20 patients, either 25%. Univariate and multivariate analysis showed that the rapid decline in renal function was associated with very high cardiovascular risk (P=0.037) and glomerular filtration rate (P˂0.001). this study showed a high hospital frequency of the rapid decline in renal function in Togo (35%). Our results have identified the very high cardiovascular risk and glomerular filtration rate as risk factors. The originality of our study was the demonstration of the high proportion of very high cardiovascular risk (82.5%) and very high renal risk (25%) in the evaluation of renal and cardiovascular risk.