Systemic inflammatory response after single-incision laparoscopic surgery versus standard laparoscopic approach

• Published in: Surgical laparoscopy, endoscopy & percutaneous techniques Vol. 22; no. 1; p. 21
• Main Authors: Ypsilantis, Petros, Didilis, Vasilios, Tsigalou, Christina, Pitiakoudis, Michael, Karakatsanis, Anastasios, Margioulas, Apostolos, Simopoulos, Constantinos
• Format: Journal Article
• Language: English
• Published: United States 01.02.2012
• Subjects: Animals; C-Reactive Protein - metabolism; Enzyme-Linked Immunosorbent Assay; Interleukin-18 - metabolism; Interleukin-6 - metabolism; Laparoscopy - adverse effects; Laparoscopy - methods; Random Allocation; Sus scrofa; Systemic Inflammatory Response Syndrome - etiology; Tumor Necrosis Factor-alpha - metabolism
• ISSN: 1534-4908
• DOI: 10.1097/SLE.0b013e318242ea5c

The extent of surgical trauma is reflected by systemic inflammatory response (SIR). The aim of this study was to assess SIR after single-incision laparoscopic surgery (SILS) versus the standard laparoscopic approach. Twenty pigs were assigned into 4 groups: SILS (group SILS), laparoscopy using 4 trocars (group LAPSC), pneumoperitoneum (group PNE), or a sham-operation (group Sham) group. Blood samples were taken at 0, 1, 3, 6, 24, and 48 hours and 1 week postoperation to measure tumor necrosis factor-α, interleukin (IL)-6, IL-18, and C-reactive protein serum levels. No significant changes were noted among groups for each time point studied regarding tumor necrosis factor-α, IL-6, and IL-18. C-reactive protein levels were significantly lower (P<0.05) in group PNE compared with the other groups at 24 hours, 48 hours, and 1 week. There is no difference in SIR after SILS versus the standard laparoscopic approach.