Echocardiographic study of left ventricular geometry in spontaneously hypertensive rats

• Published in: Medicina (Buenos Aires) Vol. 69; no. 3; pp. 335 - 340
• Main Authors: Escudero, Eduardo M, Pinilla, Oscar A, Carranza, Verónica B
• Format: Journal Article
• Language: Spanish
• Published: Argentina 2009
• Subjects: Animals; Blood Pressure - physiology; Echocardiography; Heart Rate - physiology; Heart Ventricles - diagnostic imaging; Heart Ventricles - physiopathology; Hypertension - diagnostic imaging; Hypertension - physiopathology; Male; Rats; Rats, Inbred SHR; Rats, Wistar
• ISSN: 0025-7680

The purpose of this study was to analyze by echocardiogram left ventricular (LV) geometry in spontaneously hypertensive rats (SHR). Echocardiographic study, systolic blood pressure and heart rate were obtained in 114 male, 4-month old rats, 73 SHR and 41 Wistar (W). Left ventricular mass index (LVMI), relative wall thickness (RWT), stroke volume, and mid ventricular shortening were calculated with echocardiographic parameters. Normal LV was defined considering the mean plus 2 SD of LVMI and RWT in W. Patterns of abnormal LV geometry were: LV concentric remodeling, LVMI < 2.06 mg/g - RWT > 0.71; eccentric, left ventricular hypertrophy (LVH), LVMI > 2.06 mg/g - RWT < 0.71; and concentric LVH, LVMI > 2.06 mg/g - RWT > 0.71. Systolic blood pressure (SBP) and cardiac output (CO) were used to obtain total peripheral resistance (TPR). twelve % of SHR had normal LV geometry; 18% LV concentric remodeling; 33% concentric LVH and 37% eccentric LVH. LV concentric remodeling showed the smallest CO and highest TPR of any group. Eccentric LVH presented similar SBP as the other SHR groups and high CO with lower TPR. Our findings in SHR exhibit different patterns of LV geometry like in humans. These results strengthen the similarities between SHR and human essential hypertension.