Contrast induced nephropathy in acute coronary syndrome

• Published in: Medicina (Buenos Aires) Vol. 71; no. 5; pp. 441 - 448
• Main Authors: Carnevalini, Mariana, Giorgi, Mariano, Waldman, Silvina, Caturla, Nicolás, Ovejero, Rodrigo, Falconi, Estela, San Miguel, Lucas, Caroli, Christian, Magariños, Eduardo, Cohen Arazi, Hernán
• Format: Journal Article
• Language: Spanish
• Published: Argentina 2011
• Subjects: Acute Coronary Syndrome - diagnosis; Acute Coronary Syndrome - therapy; Acute Kidney Injury - chemically induced; Age Factors; Angioplasty; Argentina - epidemiology; Contrast Media - adverse effects; Creatinine - blood; Female; Hospitalization - statistics & numerical data; Humans; Length of Stay; Male; Middle Aged; Retrospective Studies; Risk Factors; Time Factors; Argentina
• ISSN: 0025-7680

Contrast induced nephropathy (CIN) is one of the most frequent causes of acute renal failure in hospitalized patients. It is associated with an increase in morbidity and mortality in patients hospitalized for acute coronary syndrome (ACS) undergoing percutaneous coronary intervention (PCI). Risk factors and prevention strategies are not well defined. The aim of this study was to assess the incidence and clinical risk factors associated to the development of contrast induced nephropathy in patients hospitalized for ACS. In a retrospective cohort we analyzed consecutive patients hospitalized for ACS undergoing urgent PCI within 72 hours from the admission. CIN was defined as a 25% increase of creatinine levels from baseline at 48 hours from the PCI. The inclusion period was from January 1, 2004 to June 30, 2010. A total of 125 patients were analyzed, and CIN occurred in 13 (10.4%) patients. An independent association was found between age (OR 1.05; 95% CI 1.004 to 1.11; p = 0.034), multiple vessel angioplasty (OR 2.2; 95% IC 1.07 to 4.8; p = 0.03) and the volume of contrast infused (OR 1.007; 95% CI 1.001 to 1.01; p = 0.014) with the development of CIN.