A neonatal case of immunoallergic acute interstitial nephritis

Acute interstitial nephritis accounts for about 10 % of the cases of acute renal failure. An adverse drug reaction caused by an immunoallergic mechanism is suggested when fever, skin rash, eosinophilia, and eosinophiluria are associated. The outcome is favorable after withdrawal of drug therapy in m...

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Bibliographic Details
Published inArchives de pédiatrie : organe officiel de la Société française de pédiatrie Vol. 17; no. 11; pp. 1559 - 1561
Main Authors Essid, A, Allani-Essid, N, Rubinsztajn, R, Estournet, B, Bataille, J
Format Journal Article
LanguageFrench
Published France 01.11.2010
Subjects
Acute Disease
Anti-Bacterial Agents - adverse effects
Cefotaxime - adverse effects
Eosinophilia - chemically induced
Gentamicins - adverse effects
Hepatitis - etiology
Humans
Infant, Newborn
Male
Nephritis, Interstitial - chemically induced
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Summary:Acute interstitial nephritis accounts for about 10 % of the cases of acute renal failure. An adverse drug reaction caused by an immunoallergic mechanism is suggested when fever, skin rash, eosinophilia, and eosinophiluria are associated. The outcome is favorable after withdrawal of drug therapy in most cases. We report a case of acute interstitial nephritis induced by immunoallergic drug mechanisms, in a 3-week-old infant who presented with acute renal failure associated with eosinophilia and hepatitis and who had received cefotaxime and gentamicin. The patient's progression was favorable with normalization of renal and liver function 1 week after suspension of antibiotic drugs.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
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ISSN:1769-664X
DOI:10.1016/j.arcped.2010.08.014