First report of the bla(OXA-58) gene in a clinical isolate of Acinetobacter baumannii in Rio de Janeiro, Brazil

• Published in: Memórias do Instituto Oswaldo Cruz Vol. 106; no. 3; pp. 368 - 370
• Main Authors: Figueiredo, Deuseli Quaresma de, Santos, Kátia Regina Netto Dos, Pereira, Eliezer Menezes, Schuenck, Ricardo Pinto, Mendonça-Souza, Cláudia Rezende Vieira de, Teixeira, Lúcia Martins, Mondino, Silvia Susana Bona de
• Format: Journal Article
• Language: English
• Published: Brazil 01.05.2011
• Subjects: Acinetobacter baumannii - drug effects; Acinetobacter baumannii - enzymology; Acinetobacter baumannii - genetics; Acinetobacter Infections - microbiology; Anti-Bacterial Agents - pharmacology; beta-Lactamases - genetics; Disk Diffusion Antimicrobial Tests; Drug Resistance, Multiple, Bacterial; Humans; Polymerase Chain Reaction
• ISSN: 1678-8060
• DOI: 10.1590/S0074-02762011000300019

Carbapenemase production is an important mechanism of carbapenem resistance among nonfermentative Gram-negative isolates. This study aimed to report the detection of bla(OXA-58) gene in multiresistant clinical isolates of Acinetobacter baumannii recovered from inpatients in a public hospital. Polymerase chain reaction tests were performed to detect the bla(OXA-23-like), bla(OXA-24-like), bla(OXA-58-like) and bla(OXA-51-like) genes. The bla(OXA-58) and bla(OXA-23) genes were detected in one and three isolates, respectively. Sequencing of the bla(OXA-58-like) amplicon revealed 100% identity with the A. baumannii bla(OXA-58) gene listed in the GenBank database. This is the first report of an OXA-58-producing A. baumannii isolate in Rio de Janeiro, Brazil.