Umbilical cord hematopoietic precursors transplantation. Report of five patients

Hematopoietic precursors transplantation is a therapeutic alternative for leukemia, some metabolic diseases and some immune deficiency syndromes. In its allogeneic variety leukemia eradication is based in the conditioning prior to transplantation and the allograñ effect against leukemia. Umbilical c...

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Published inRevista medíca de Chile Vol. 137; no. 8; pp. 1054 - 1060
Main Authors Burotto P, Mauricio, Bertín C-M, Pablo, Galindo A, Héctor, Garrido S, Marcelo, Melgoza P, Geraldine, Nervi N, Bruno, Ramírez V, Pablo, Ocqueteau T, Mauricio, Besa de C, Pelayo, García V, Verónica, Jara A, Verónica, Alvarez J, Elvira, Betancur B, Maritsa, Rivera L, Mirtza, Alvarez Z, Manuel
Format Journal Article
LanguageSpanish
Published Chile 01.08.2009
Subjects
Adolescent
Adult
Chile
Cord Blood Stem Cell Transplantation - adverse effects
Fatal Outcome
Female
Hematopoietic Stem Cell Transplantation - adverse effects
Humans
Leukemia, Myeloid - surgery
Male
Middle Aged
Remission Induction
Transplantation Conditioning
Young Adult
Chile
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Summary:Hematopoietic precursors transplantation is a therapeutic alternative for leukemia, some metabolic diseases and some immune deficiency syndromes. In its allogeneic variety leukemia eradication is based in the conditioning prior to transplantation and the allograñ effect against leukemia. Umbilical cord blood is an alternative source of hematopoietic precursors when there are no HLA compatible relatives available. Between 2003 and 2007 we have performed five umbilical cord blood transplant in adult patients in a University hospital. All patients had malignant diseases. Conditioning protocols were ablative in all except in one patient and in all, more than one unit of umbilical cord blood was used. Hematopoietic engraftment was confirmed in all patients and the main complications registered were infectious and associated to immunosuppression.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
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ISSN:0034-9887