Sphenoid sinusitis with intracranial extension produced by an emergent fungus

This is a case of fungal sphenoid sinusitis in a diabetic patient with non-specific symptoms and bone erosion radiological findings in the superior and posterior sphenoid walls. Surgical treatment was performed by transnasal endoscopic approach and voriconazole orally thereafter. The histopathologic...

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Bibliographic Details
Published inActa otorrinolaringologica espanola Vol. 62; no. 2; p. 158
Main Authors Escamilla Carpintero, Yolanda, Espasa Soley, Mateu, Bella Cueto, M Rosa, Prenafeta Moreno, Mario
Format Journal Article
LanguageSpanish
Published Spain 01.03.2011
Subjects
Aged
Antifungal Agents - therapeutic use
Ascomycota - classification
Ascomycota - isolation & purification
Biopsy
Combined Modality Therapy
Communicable Diseases, Emerging - microbiology
Comorbidity
Diabetes Mellitus, Type 2 - complications
Disease Susceptibility
Female
Headache - etiology
Humans
Magnetic Resonance Imaging
Mycoses - complications
Mycoses - drug therapy
Mycoses - microbiology
Mycoses - pathology
Mycoses - surgery
Osteolysis - etiology
Osteosclerosis - etiology
Pyrimidines - therapeutic use
Sphenoid Bone - pathology
Sphenoid Sinusitis - complications
Sphenoid Sinusitis - drug therapy
Sphenoid Sinusitis - microbiology
Sphenoid Sinusitis - pathology
Sphenoid Sinusitis - surgery
Tomography, X-Ray Computed
Triazoles - therapeutic use
Voriconazole
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Summary:This is a case of fungal sphenoid sinusitis in a diabetic patient with non-specific symptoms and bone erosion radiological findings in the superior and posterior sphenoid walls. Surgical treatment was performed by transnasal endoscopic approach and voriconazole orally thereafter. The histopathological study found fungus hyphal without mucosa invasion and the molecular study determined DNA to be Phialemonium curvatum, an unusual pathogen.
ISSN:1988-3013
DOI:10.1016/j.otorri.2010.01.010