Early biomarkers of acute kidney failure after heart angiography or heart surgery in patients with acute coronary syndrome or acute heart failure

• Published in: Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia Vol. 32; no. 1; p. 44
• Main Authors: Torregrosa, Isidro, Montoliu, Carmina, Urios, Amparo, Elmlili, Nisrin, Puchades, María Jesús, Solís, Miguel Angel, Sanjuán, Rafael, Blasco, Maria Luisa, Ramos, Carmen, Tomás, Patricia, Ribes, José, Carratalá, Arturo, Juan, Isabel, Miguel, Alfonso
• Format: Journal Article
• Language: English
• Published: Spain 2012
• Subjects: Acute Coronary Syndrome - surgery; Acute Disease; Acute Kidney Injury - blood; Acute Kidney Injury - diagnosis; Acute Kidney Injury - etiology; Acute Kidney Injury - urine; Acute-Phase Proteins - urine; Aged; Biomarkers - blood; Biomarkers - urine; Cardiac Catheterization - adverse effects; Cardiac Surgical Procedures - adverse effects; Coronary Angiography - adverse effects; Cystatin C - blood; Early Diagnosis; Female; Heart Failure - surgery; Humans; Interleukin-18 - urine; Lipocalin-2; Lipocalins - urine; Male; Middle Aged; Proto-Oncogene Proteins - urine; Sensitivity and Specificity
• ISSN: 1989-2284
• DOI: 10.3265/Nefrologia.pre2011.Sep.10988

Acute kidney injury (AKI) is a common complication in cardiac surgery and coronary angiography, which worsens patients' prognosis. The diagnosis is based on the increase in serum creatinine, which is delayed. It is necessary to identify and validate new biomarkers that allow for early and effective interventions. To assess the sensitivity and specificity of neutrophil gelatinase-associated lipocalin in urine (uNGAL), interleukin-18 (IL-18) in urine and cystatin C in serum for the early detection of AKI in patients with acute coronary syndrome or heart failure, and who underwent cardiac surgery or catheterization. The study included 135 patients admitted to the intensive care unit for acute coronary syndrome or heart failure due to coronary or valvular pathology and who underwent coronary angiography or cardiac bypass surgery or valvular replacement. The biomarkers were determined 12 hours after surgery and serum creatinine was monitored during the next six days for the diagnosis of AKI. The area under the ROC curve (AUC) for NGAL was 0.983, and for cystatin C and IL-18 the AUCs were 0.869 and 0.727, respectively. At a cut-off of 31.9 ng/ml for uNGAL the sensitivity was 100% and the specificity was 91%. uNGAL is an early marker of AKI in patients with acute coronary syndrome or heart failure and undergoing cardiac surgery and coronary angiography, with a higher predictive value than cystatin C or IL-18.