Two cases of serious hepatic injury caused by antithyroid drugs

We present two cases of severe hepatotoxicity caused by antithyroid drugs in women with Graves disease. The first medication in both cases was methimazole replaced by propylhiouracil due to intolerance. The main symptom was jaundice lasting about 2 months. As a first step in the treatment we termina...

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Bibliographic Details
Published inEndokrynologia polska Vol. 60; no. 5; p. 396
Main Authors Grzywa, Marek, Orłowska-Florek, Renata, Grzywa-Celińska, Anna
Format Journal Article
LanguagePolish
Published Poland 01.09.2009
Subjects
Antithyroid Agents - adverse effects
Chemical and Drug Induced Liver Injury - etiology
Female
Graves Disease - drug therapy
Graves Disease - radiotherapy
Humans
Iodine Radioisotopes - therapeutic use
Jaundice - chemically induced
Methimazole - adverse effects
Middle Aged
Prednisone - therapeutic use
Propylthiouracil - adverse effects
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Summary:We present two cases of severe hepatotoxicity caused by antithyroid drugs in women with Graves disease. The first medication in both cases was methimazole replaced by propylhiouracil due to intolerance. The main symptom was jaundice lasting about 2 months. As a first step in the treatment we terminated the antithyroid drug administration and introduced prednisone and ursodesoksycholic acid therapy. The termination of thyrotoxicosis by means of 131 I administration had also positive influence on the course of disease. In summary we emphasise the significance of prompt discontinuation of antithyroid drug once toxic symptoms appeared and avoid replacement one thyrostatic drug for another in fovour of radioiodine treatment.
ISSN:0423-104X