The effect of dapagliflozin ointment on induced psoriasis in an experimental model

• Published in: Journal of medicine and life Vol. 17; no. 3; pp. 281 - 285
• Main Authors: Al Bahadly, Waleed Khaled Younis, Bdioui, Ahlem, Al-Gazally, Moaed, Al-Saedi, Haider, Salah, Sihem Hmissa Belhaj, Ramadhan, Mukhallad
• Format: Journal Article
• Language: English
• Published: Romania Carol Daila University Foundation 01.03.2024; Carol Davila University Press
• Subjects: Albinism; Animals; Benzhydryl Compounds - pharmacology; Biomarkers; Cytokines; Cytokines - metabolism; Diabetes; Disease Models, Animal; Erythema; Glucose; Glucosides - administration & dosage; Glucosides - pharmacology; Glucosides - therapeutic use; Imiquimod; Inflammation; Keratin; Male; Mice; Ointments; Original; Psoriasis; Psoriasis - chemically induced; Psoriasis - drug therapy; Psoriasis - pathology; Tumor necrosis factor-TNF; Variance analysis; mice; dapagliflozin; psoriasis; imiquimod
• DOI: 10.25122/jml-2023-0084
• ISSN: 1844-122X; 1844-3117

Dapagliflozin is a pharmacological drug commonly used to manage type 2 diabetes by inhibiting the sodium-glucose cotransporter in the proximal renal tubules. The primary objective of this research was to develop a topical ointment formulation containing dapagliflozin and assess its efficacy in treating psoriasis using an imiquimod-induced psoriasis model. A total of 16 Swiss albino mice, with weights ranging from 24 to 30 grams, were allocated randomly into six groups, each group including ten animals. The study assessed the effects of various concentrations of dapagliflozin ointment on levels of tumor necrosis factor-alpha (TNF-alpha), interleukin-8 (IL-8), IL-17, and IL-37, as well as on erythema, scaling, and epidermal thickness. Dapagliflozin ointment significantly reduced these cytokine levels and disease scores, indicating anti-psoriatic and anti-inflammatory properties. Therefore, when applied topically, dapagliflozin ointment had strong efficacy against imiquimod-induced psoriatic skin inflammation, suggesting its potential as a novel therapeutic option for psoriasis treatment.