The effect of dapagliflozin ointment on induced psoriasis in an experimental model

Dapagliflozin is a pharmacological drug commonly used to manage type 2 diabetes by inhibiting the sodium-glucose cotransporter in the proximal renal tubules. The primary objective of this research was to develop a topical ointment formulation containing dapagliflozin and assess its efficacy in treat...

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Published inJournal of medicine and life Vol. 17; no. 3; pp. 281 - 285
Main Authors Al Bahadly, Waleed Khaled Younis, Bdioui, Ahlem, Al-Gazally, Moaed, Al-Saedi, Haider, Salah, Sihem Hmissa Belhaj, Ramadhan, Mukhallad
Format Journal Article
LanguageEnglish
Published Romania Carol Daila University Foundation 01.03.2024
Carol Davila University Press
Subjects
Albinism
Animals
Benzhydryl Compounds - pharmacology
Biomarkers
Cytokines
Cytokines - metabolism
Diabetes
Disease Models, Animal
Erythema
Glucose
Glucosides - administration & dosage
Glucosides - pharmacology
Glucosides - therapeutic use
Imiquimod
Inflammation
Keratin
Male
Mice
Ointments
Original
Psoriasis
Psoriasis - chemically induced
Psoriasis - drug therapy
Psoriasis - pathology
Tumor necrosis factor-TNF
Variance analysis
mice
dapagliflozin
psoriasis
imiquimod
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Summary:Dapagliflozin is a pharmacological drug commonly used to manage type 2 diabetes by inhibiting the sodium-glucose cotransporter in the proximal renal tubules. The primary objective of this research was to develop a topical ointment formulation containing dapagliflozin and assess its efficacy in treating psoriasis using an imiquimod-induced psoriasis model. A total of 16 Swiss albino mice, with weights ranging from 24 to 30 grams, were allocated randomly into six groups, each group including ten animals. The study assessed the effects of various concentrations of dapagliflozin ointment on levels of tumor necrosis factor-alpha (TNF-alpha), interleukin-8 (IL-8), IL-17, and IL-37, as well as on erythema, scaling, and epidermal thickness. Dapagliflozin ointment significantly reduced these cytokine levels and disease scores, indicating anti-psoriatic and anti-inflammatory properties. Therefore, when applied topically, dapagliflozin ointment had strong efficacy against imiquimod-induced psoriatic skin inflammation, suggesting its potential as a novel therapeutic option for psoriasis treatment.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1844-122X
1844-3117
1844-3117
DOI:10.25122/jml-2023-0084