Functional significance of monoamine- and aminoacidergic mechanisms of dorsal pallidum in anxiety of different aversive genesis

Microinjections of serotonin and glutamine acid into the globus pallidus reveal antiaversive properties of these subsrances in the test with avoiding "threatening situation" but not "illuminated site" test under conditions of rats' free choice between light and dark sites. D...

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Bibliographic Details
Published inZurnal vyss̆ej nervnoj dejatelnosti imeni I P Pavlova Vol. 57; no. 1; p. 86
Main Authors Talalaenko, A N, Krivobok, G K, Bulgakova, N P, Pankrat'ev, D V
Format Journal Article
LanguageRussian
Published Russia (Federation) 01.01.2007
Subjects
Amino Acids - pharmacology
Amino Acids - physiology
Animals
Anxiety - etiology
Anxiety - physiopathology
Anxiety - psychology
Behavior, Animal
Biogenic Monoamines - pharmacology
Biogenic Monoamines - physiology
Escape Reaction - drug effects
Globus Pallidus - drug effects
Globus Pallidus - physiology
Globus Pallidus - physiopathology
Glutamic Acid - pharmacology
Glutamic Acid - physiology
Male
Rats
Serotonin - pharmacology
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Summary:Microinjections of serotonin and glutamine acid into the globus pallidus reveal antiaversive properties of these subsrances in the test with avoiding "threatening situation" but not "illuminated site" test under conditions of rats' free choice between light and dark sites. Dopamine and GABA injected locally into this formation of basal ganglia do not affect the mechanisms of voluntary movement, but counteract the conditions of anxiety in both models of behavior. The results testify to unequal involvement of neurotransmitter systems of the dorsal pallidum into operative regulation of behavior with changes of aversive stimulus modality.
ISSN:0044-4677