Activation of glutamate ionotropic connections of sensorimotor cortex neurons during conditioning

• Published in: Zurnal vyss̆ej nervnoj dejatelnosti imeni I P Pavlova Vol. 52; no. 3; p. 292
• Main Authors: Storozhuk, V M, Khorevin, V I, Razumna, N N, Tetko, I V, Villa, A P
• Format: Journal Article
• Language: Russian
• Published: Russia (Federation) 01.05.2002
• Subjects: 2-Amino-5-phosphonovalerate - analogs & derivatives; 2-Amino-5-phosphonovalerate - pharmacology; 6-Cyano-7-nitroquinoxaline-2,3-dione - pharmacology; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid - metabolism; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid - pharmacology; Animals; Axons; Bicuculline - pharmacology; Cats; Conditioning, Classical; Dizocilpine Maleate - pharmacology; Excitatory Amino Acid Antagonists - pharmacology; GABA Antagonists - pharmacology; gamma-Aminobutyric Acid - metabolism; gamma-Aminobutyric Acid - pharmacology; Glutamic Acid - metabolism; Interneurons - physiology; N-Methylaspartate - metabolism; N-Methylaspartate - pharmacology; Neural Inhibition; Pyramidal Cells - physiology; Receptors, AMPA - metabolism; Receptors, N-Methyl-D-Aspartate - metabolism; Somatosensory Cortex - drug effects; Somatosensory Cortex - physiology
• ISSN: 0044-4677

Changes in conditioned impulse reactions of neurons in sensorimotor cortex were studied during microiontophoretic application of glutamatergic and GABA ergic agonistic and antagonistic drugs. It was shown that ionotropic glutamate receptors (AMPA and NMDA) are activated by a conditioned stimulus. Not only large pyramidal neurons of deep cortical layers but surrounding short-axon inhibitory interneurons are involved in the reaction. It was shown that the activity of pyramidal neurons is under a constant inhibitory control from surrounding interneurons. This inhibition is involved in organization of excitatory cortical responses during conditioning.