Predictive clinical factors of response to subthalamic nucleus stimulation in Parkinson's disease

Subthalamic nucleus stimulation (SNE) is currently a reasonable treatment for patients with advanced Parkinson's disease (PD). Predictive factors for effective SNE have not yet been identified with precision. We have prospectively evaluated response to SNE in a series of patients with advanced...

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Bibliographic Details
Published inNeurología (Barcelona, Spain) Vol. 22; no. 1; p. 1
Main Authors Garcia, P J, Muñiz de Igneson, J, Ayerbe, J, Alonso Frech, F, García Torres, A, Contreras, A, Magariños Ascone, C
Format Journal Article
LanguageSpanish
Published Spain 01.01.2007
Subjects
Deep Brain Stimulation - instrumentation
Deep Brain Stimulation - methods
Humans
Middle Aged
Parkinson Disease - surgery
Parkinson Disease - therapy
Prospective Studies
Prostheses and Implants
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Summary:Subthalamic nucleus stimulation (SNE) is currently a reasonable treatment for patients with advanced Parkinson's disease (PD). Predictive factors for effective SNE have not yet been identified with precision. We have prospectively evaluated response to SNE in a series of patients with advanced PD to study the factors that influence clinical improvement after functional surgery. We prospectively studied 20 patients with advanced PD (age: 59 +/-6.1; stage: 3.0+/-0.8) candidates for SNE. We studied these patients preoperatively and 6 months postoperatively according to Core Assessment Program for Intracerebral Transplantation (CAPIT) protocol including timed tests. We found a negative correlation between age and Unified Parkinson Disease Rating Scale (UPDRS) improvement; however, age did not correlate with timed tests improvement. In addition, preoperative severity (UPDRS and Hoehn-Yahr) did not correlate with UPDRS and timed tests improvement. In summary, age is a negative predictor for effective SNE.
ISSN:0213-4853