Substituted 4-phenyl-2-(phenylcarboxamido)-1,3-thiazole derivatives as antagonists for the adenosine A(1) receptor

The synthesis and receptor binding of novel adenosine receptor antagonists is described. We found that non-xanthine 4-phenyl-2-(phenylcarboxamido)-1,3-thiazole derivatives may have high affinity and substantial selectivity for the adenosine A(1) receptor.

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Bibliographic Details
Published inBioorganic & medicinal chemistry letters Vol. 11; no. 15; pp. 2017 - 2019
Main Authors van Tilburg, E W, van der Klein, P A, de Groote, M, Beukers, M W, IJzerman, A P
Format Journal Article
LanguageEnglish
Published England 06.08.2001
Subjects
Animals
Cells, Cultured
Humans
Protein Binding - physiology
Purinergic P1 Receptor Antagonists
Rats
Receptor, Adenosine A2A
Receptor, Adenosine A3
Receptors, Purinergic P1 - drug effects
Thiazoles - chemical synthesis
Thiazoles - pharmacology
Visual Cortex - cytology
Visual Cortex - metabolism
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Summary:The synthesis and receptor binding of novel adenosine receptor antagonists is described. We found that non-xanthine 4-phenyl-2-(phenylcarboxamido)-1,3-thiazole derivatives may have high affinity and substantial selectivity for the adenosine A(1) receptor.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:0960-894X
1464-3405
DOI:10.1016/S0960-894X(01)00356-0