Myelointegration of titanium implants: B lymphopoiesis and hemopoietic cell proliferation in mouse bone marrow exposed to titanium implants

Multinucleated giant cells have been observed at interfaces between bone marrow and titanium implants in mouse femurs. This raises concern that macrophage-derived factors might perturb local lymphohemopoiesis, possibly even predisposing to neoplasia in the B lymphocyte lineage. It has been found tha...

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Published inThe International journal of oral and maxillofacial implants Vol. 15; no. 2; p. 175
Main Authors Rahal, M D, Delorme, D, Brånemark, P I, Osmond, D G
Format Journal Article
LanguageEnglish
Published United States 01.03.2000
Subjects
Analysis of Variance
Animals
B-Lymphocytes - physiology
Biocompatible Materials - chemistry
Bone Marrow Cells - physiology
Bone Neoplasms - etiology
Bone Regeneration - physiology
Cell Count
Cell Division
Cell Lineage
Dental Implants
Disease Susceptibility
Femur - pathology
Giant Cells - physiology
Hematopoietic Stem Cells - physiology
Leukopoiesis - physiology
Macrophages - physiology
Male
Mice
Mice, Inbred C3H
Mice, Inbred Strains
Osseointegration
Surface Properties
Time Factors
Titanium - chemistry
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Summary:Multinucleated giant cells have been observed at interfaces between bone marrow and titanium implants in mouse femurs. This raises concern that macrophage-derived factors might perturb local lymphohemopoiesis, possibly even predisposing to neoplasia in the B lymphocyte lineage. It has been found that an implant-marrow interface with associated giant cells persists for at least 1.5 years. Precursor B cells show early increases in number and proliferative activity. At later intervals, however, they do not differ significantly from controls, and there are no perturbations in spatial localization of either B lineage cells or DNA-synthesizing hemopoietic cells. The results of this investigation in mice demonstrate that, following initial marrow regeneration and fluctuating precursor B cell activity, and despite the presence of giant cells, titanium implants apparently become well-tolerated by directly apposed bone marrow cells in a lasting state of "myelointegration."
ISSN:0882-2786