Diabetic nephropathy: risk factors of rapid progression of renal failure

To reveal factors accelerating development of chronic renal failure (CRF) in patients with insulin-dependent diabetes mellitus type I (DM-I). A retrospective analysis of case histories was made for 40 patients with DM-I exhibiting progression of proteinuric stage of diabetic nephropathy prior to CRF...

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Bibliographic Details
Published inTerapevtic̆eskii arhiv Vol. 71; no. 6; p. 45
Main Authors Shestakova, M V, Chugunova, L A, Shamkhalova, M Sh, Dirochka, Iu A, Dedov, I I
Format Journal Article
LanguageRussian
Published Russia (Federation) 1999
Subjects
Adolescent
Adult
Blood Pressure
Cholesterol - blood
Creatinine - blood
Diabetes Mellitus, Type 1 - blood
Diabetes Mellitus, Type 1 - complications
Diabetes Mellitus, Type 1 - urine
Diabetic Nephropathies - complications
Diabetic Nephropathies - metabolism
Diabetic Nephropathies - physiopathology
Disease Progression
Female
Follow-Up Studies
Glycated Hemoglobin A - metabolism
Humans
Hyperlipidemias - blood
Hyperlipidemias - complications
Hypertension, Renal - complications
Hypertension, Renal - metabolism
Hypertension, Renal - physiopathology
Kidney Failure, Chronic - etiology
Kidney Failure, Chronic - metabolism
Kidney Failure, Chronic - physiopathology
Male
Prognosis
Proteinuria - blood
Proteinuria - complications
Proteinuria - urine
Retrospective Studies
Risk Factors
Triglycerides - blood
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Summary:To reveal factors accelerating development of chronic renal failure (CRF) in patients with insulin-dependent diabetes mellitus type I (DM-I). A retrospective analysis of case histories was made for 40 patients with DM-I exhibiting progression of proteinuric stage of diabetic nephropathy prior to CRF stage. Clinical-laboratory indices were compared for patients with slow (group 1, n = 17) and fast (group 2, n = 23) development of CRF. Patients of group 2 had significantly higher levels of glycosylated hemoglobin, total cholesterol, triglycerides in the blood, urine protein excretion, systolic and diastolic blood pressure than patients of group 1. Also, patients of group 2 had not taken antihypertensive drugs regularly. Factors of risk of CRF early development of DM-I patients comprise unsatisfactory compensation of carbohydrate metabolism, hyperlipidemia, high proteinuria, arterial hypertension and inadequate antihypertensive therapy.
ISSN:0040-3660