Effect of ubiquinone Q(10) and antioxidant vitamins on free radical oxidation of phospholipids in biological membranes of rat liver

• Published in: Bulletin of experimental biology and medicine Vol. 140; no. 2; pp. 181 - 183
• Main Authors: Tikhaze, A K, Konovalova, G G, Lankin, V Z, Kaminnyi, A I, Kaminnaja, V I, Ruuge, E K, Kukharchuk, V V
• Format: Journal Article
• Language: English
• Published: United States 01.08.2005
• Subjects: Animals; Antioxidants - chemistry; Antioxidants - metabolism; Antioxidants - pharmacology; Ascorbic Acid - metabolism; beta Carotene - metabolism; Coenzymes; Free Radicals; Kinetics; Liver - metabolism; Liver Extracts - metabolism; Male; Models, Chemical; Oxidation-Reduction; Oxygen - metabolism; Phospholipids - chemistry; Rats; Rats, Wistar; Time Factors; Ubiquinone - analogs & derivatives; Ubiquinone - pharmacology; Vitamins
• ISSN: 0007-4888
• DOI: 10.1007/s10517-005-0439-3

We studied the effects of 30-day peroral treatment with beta-carotene, a complex of antioxidant vitamins (vitamins C and E and provitamin A) and selenium, and solubilized ubiquinone Q(10) on the antioxidant potential in rat liver (ascorbate-dependent free radical oxidation of unsaturated membrane phospholipids). beta-Carotene irrespective of the administration route increased antioxidant potential of the liver by 2-3.5 times. The complex of antioxidant vitamins and selenium increased this parameter by more than 15 times. Antiradical activity in rat liver was extremely high after administration of solubilized ubiquinone Q(10) (increase by more than by 36 times). It can be expected that reduced ubiquinone Q(10) in vivo should produce a more pronounced protective effect due to activity of the system for bioregeneration of this natural antioxidant.