Primary thyroid lymphomas: clinicopathologic study of 30 cases and review of the literature

During a both retrospective and prospective study of thyroid cancers treated in the Basse Normandie between 1960 and 1999, we have identified 32 patients with thyroid lymphoma. The correct diagnosis was made initially in 69% of all cases. In the other cases, the diagnosis was secondarily corrected a...

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Bibliographic Details
Published inAnnales de pathologie Vol. 22; no. 1; p. 10
Main Authors Michels, Jean-Jacques, Delcambre, Corinne, Marnay, Jacques, Denoux, Yves, Peny, Anne-Marie, Chasle, Jacques
Format Journal Article
LanguageFrench
Published France 01.02.2002
Subjects
Adult
Aged
Aged, 80 and over
Female
Humans
Immunohistochemistry
Lymphoma - diagnosis
Lymphoma - mortality
Lymphoma - pathology
Lymphoma - therapy
Lymphoma, B-Cell, Marginal Zone - diagnosis
Lymphoma, B-Cell, Marginal Zone - pathology
Male
Middle Aged
Neoplasm Staging
Plasmacytoma - diagnosis
Plasmacytoma - pathology
Prognosis
Survival Rate
Thyroid Neoplasms - diagnosis
Thyroid Neoplasms - mortality
Thyroid Neoplasms - pathology
Thyroid Neoplasms - therapy
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Summary:During a both retrospective and prospective study of thyroid cancers treated in the Basse Normandie between 1960 and 1999, we have identified 32 patients with thyroid lymphoma. The correct diagnosis was made initially in 69% of all cases. In the other cases, the diagnosis was secondarily corrected after review of the pathological material. According to the REAL classification, 7 (21%) corresponded to low grade MALT lymphomas, 2 to low grade lymphomas, 10 to high grade MALT Lymphomas and 10 (31%) to high grade lymphomas, one plasmocytoma and two unclassified lymphomas. According to the Ann Arbor classification, stage was IE for 56%, IIE for 19%, IIIE for 3% and 9% for IV. Median survival was 28 months with a mean at 61 months. 20 patients died (62%), 12 from the lymphoma and 8 from intercurrent causes. The overall survival at 5 years was 36% (9 5% CI 16 54%). A comparison of our results with those of the literature was performed.
ISSN:0242-6498