Chronic urticaria, thyroiditis and autologous serum test

The autoimmune nature of certain forms of chronic urticaria remains debatable. Aim of the study. To find a correlation in terms of autoimmune pattern between chronic urticaria and thyroiditis using the autologous serum test and the search for anti-thyroid antibodies. Study in a single center of 59 p...

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Published inAnnales de dermatologie et de vénéréologie Vol. 130; no. 12 Pt 1; p. 1115
Main Authors Vermeulen, C, Mathelier-Fusade, P, Rouquette, A-M, Bayrou, O, Pecquet, C, Leynadier, F
Format Journal Article
LanguageFrench
Published France 01.12.2003
Subjects
Adolescent
Adult
Aged
Autoantibodies - blood
Child
Chronic Disease
Female
Humans
Male
Middle Aged
Thyroiditis, Autoimmune - blood
Thyroiditis, Autoimmune - diagnosis
Urticaria - blood
Urticaria - diagnosis
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Summary:The autoimmune nature of certain forms of chronic urticaria remains debatable. Aim of the study. To find a correlation in terms of autoimmune pattern between chronic urticaria and thyroiditis using the autologous serum test and the search for anti-thyroid antibodies. Study in a single center of 59 patients having consulted for urticaria that had progressed for more than six weeks and without precise etiology. An autologous serum test was conducted and anti-thyroid autoantibodies were searched for in the serum stored after the test. Out of 59 patients, 51 had an interpretable autologous serum test and 57 underwent research for anti-thyroid antibodies. Twelve patients out 57 (21 p.cent) exhibited one or more types of positive (n=10) or borderline (n=2) anti-thyroid antibodies, and eight out of 12 (66.6 p.cent) had a known thyroid disease before the onset of urticaria. The systematic blood test permitted the discovery of 4 cases of unknown anti-thyroid antibodies. The symptoms regressed in two of these patients without any specific treatment, one patient was treated with L thyroxin for hyperthyroidism without any improvement in the symptoms and one other patient had normal thyroid function. Among these 12 patients, 11 underwent autologous serum tests, but only 3 of them exhibited clearly positive results and one was doubtful. Within the limits of this study, we found a 21 p.cent rate of patients with chronic urticaria exhibiting one or more anti-thyroid antibodies. The positivity of the autologous serum test does not appear to be related with autoimmune thyroid disorders.
ISSN:0151-9638