Preeclampsia increases the risk of hyaline membrane disease in premature infant: a retrospective controlled study

• Published in: Journal de gynécologie, obstétrique et biologie de la reproduction Vol. 37; no. 6; pp. 597 - 601
• Main Authors: Cherif, A, Ben jemaa, W, Kacem, S, Guellouze, N, Jebnoun, S, Khrouf, N
• Format: Journal Article
• Language: French
• Published: France 01.10.2008
• Subjects: Adult; Case-Control Studies; Confidence Intervals; Female; Humans; Hyaline Membrane Disease - epidemiology; Hyaline Membrane Disease - etiology; Infant, Low Birth Weight; Infant, Newborn; Infant, Premature; Logistic Models; Multivariate Analysis; Odds Ratio; Pre-Eclampsia - epidemiology; Pregnancy; Pregnancy Complications - epidemiology; Retrospective Studies; Risk Factors; Tunisia - epidemiology; Tunisia
• ISSN: 0368-2315
• DOI: 10.1016/j.jgyn.2008.03.008

Relation between preeclampsia (PE) and hyaline membrane disease (HMD) is still controversial. We found interesting to contribute to the study of this relation by comparing a HMD group to a control group with the aim to know if the risk to develop HMD was more important in case of PE. Two groups of premature infants (HMD group and control group) weighing less than 2000g and hospitalized between 1st January 2004 and 31st December 2005, were compared for data concerning mother (age, parity, diabetes, corticotherapy), PE (severity, complications, type and treatment), delivery (mode, infectious context, perinatal asphyxia) and neonatal stay (gestational age, birth, weight, sex). A multivariate analysis by logistic regression was used to control the effect of potential confounding variables that were considered risk factors for HMD. Ninety-seven neonates were retained and were compared to 97 control. PE was present in 71 cases in HMD group and in 51 cases of control group. This difference was statistically very significant (p=0.003). When we controlled for confounding variables, there was a significant increase in risk to develop HMD (odds ratio, 1.3; 95% confidence interval, 0.7-1.8). The risk to develop HMD, in premature infant weighing less than 2000g, is increased in case of PE. These finding support that fetal lung maturity is not accelerated in PE, in the opposite, it is delayed.