The link between IFN-γ and allograft arteriopathy: is the answer NO?

Vascularized organ transplants often fail because of smooth muscle cell migration and proliferation in the intima of graft arteries, leading to progressive lumenal narrowing and resultant ischemic damage. Graft arterial disease is caused by IFN-γ secreted by alloreactive T cells. New evidence indica...

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Bibliographic Details
Published inThe Journal of clinical investigation Vol. 114; no. 6; pp. 762 - 764
Main Authors Mitchell, Richard N., Lichtman, Andrew H.
Format Journal Article
LanguageEnglish
Published American Society for Clinical Investigation 15.09.2004
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Summary:Vascularized organ transplants often fail because of smooth muscle cell migration and proliferation in the intima of graft arteries, leading to progressive lumenal narrowing and resultant ischemic damage. Graft arterial disease is caused by IFN-γ secreted by alloreactive T cells. New evidence indicates that IFN-γ dysregulates expression of the enzymes eNOS and iNOS in graft-infiltrating leukocytes. Dysregulated NO synthase expression occurs prior to and is causally linked to intimal smooth muscle cell accumulation.
Bibliography:Address correspondence to: Andrew H. Lichtman, Department of Pathology, Brigham and Women’s Hospital, Harvard Medical School, 77 Avenue Louis Pasteur, NRB7, Boston, Massachusetts 02115, USA. Phone: (617) 525-4335; Fax: (617) 525-4333; E-mail: alichtman@rics.bwh.harvard.edu
ISSN:0021-9738
DOI:10.1172/JCI200422927