The link between IFN-γ and allograft arteriopathy: is the answer NO?
Vascularized organ transplants often fail because of smooth muscle cell migration and proliferation in the intima of graft arteries, leading to progressive lumenal narrowing and resultant ischemic damage. Graft arterial disease is caused by IFN-γ secreted by alloreactive T cells. New evidence indica...
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Published in | The Journal of clinical investigation Vol. 114; no. 6; pp. 762 - 764 |
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Main Authors | , |
Format | Journal Article |
Language | English |
Published |
American Society for Clinical Investigation
15.09.2004
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Online Access | Get full text |
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Summary: | Vascularized organ transplants often fail because of smooth muscle cell migration and proliferation in the intima of graft arteries, leading to progressive lumenal narrowing and resultant ischemic damage. Graft arterial disease is caused by IFN-γ secreted by alloreactive T cells. New evidence indicates that IFN-γ dysregulates expression of the enzymes eNOS and iNOS in graft-infiltrating leukocytes. Dysregulated NO synthase expression occurs prior to and is causally linked to intimal smooth muscle cell accumulation. |
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Bibliography: | Address correspondence to: Andrew H. Lichtman, Department of Pathology, Brigham and Women’s Hospital, Harvard Medical School, 77 Avenue Louis Pasteur, NRB7, Boston, Massachusetts 02115, USA. Phone: (617) 525-4335; Fax: (617) 525-4333; E-mail: alichtman@rics.bwh.harvard.edu |
ISSN: | 0021-9738 |
DOI: | 10.1172/JCI200422927 |