Neonatal screening program at the university hospital of the Ribeirão Preto School of Medicine, São Paulo University, Brazil

• Published in: Cadernos de saúde pública Vol. 25; no. 2; pp. 445 - 454
• Main Authors: Magalhães, Patrícia Künzle Ribeiro, Turcato, Marlene de Fátima, Angulo, Ivan de Lucena, Maciel, Léa Maria Zanini
• Format: Journal Article
• Language: Portuguese
• Published: Brazil 01.02.2009
• Subjects: Brazil; Congenital Hypothyroidism - diagnosis; Hemoglobinopathies - diagnosis; Hospitals, University - statistics & numerical data; Humans; Infant, Newborn; Neonatal Screening - methods; Neonatal Screening - standards; Phenylketonurias - diagnosis; Retrospective Studies; Brazil
• ISSN: 1678-4464
• DOI: 10.1590/S0102-311X2009000200023

The Neonatal Screening Program at the University Hospital of the Ribeirão Preto School of Medicine, São Paulo University, Brazil, was introduced in 1994. As of December 2005, congenital hypothyroidism had been diagnosed in 76 infants, phenylketonuria in 10, and hemoglobinopathies in 25, representing incidence rates of 1:2,595, 1:19,409, and 1:4,120, respectively. A total of 2,747 newborns had the sickle cell trait, i.e., were heterozygous for the sickle mutation (1:37.5 live births). The program's mean coverage during this period was 94.5%. There was major improvement in the parameters for evaluating the program's quality, although they were still far from ideal. Public-awareness campaigns on the importance of neonatal screening are needed to increase the program's coverage. Setting postnatal day 3 as the standard Day for the Heel Stick Test would help ensure treatment at earlier ages, thus improving prognosis for affected infants.