Relationship between micro- and minisatellites in the human genome

Micro- and minisatellites constitute an essential part of DNA with a low sequence complexity and carry several important functions. A search for tandem repeats in the human genome with a length of a repeat unit of up to 70 bp, including repeats with a great number of nucleotide substitutions, has be...

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Bibliographic Details
Published inBiofizika Vol. 51; no. 4; p. 650
Main Authors Boeva, V A, Fridman, M V, Makeev, V Iu
Format Journal Article
LanguageRussian
Published Russia (Federation) 01.07.2006
Subjects
Evolution, Molecular
Genome, Human - genetics
Humans
Microsatellite Repeats - genetics
Minisatellite Repeats - genetics
Models, Genetic
Software
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Summary:Micro- and minisatellites constitute an essential part of DNA with a low sequence complexity and carry several important functions. A search for tandem repeats in the human genome with a length of a repeat unit of up to 70 bp, including repeats with a great number of nucleotide substitutions, has been performed using the TaadeaSWAN program. It was shown that, for a considerable number of minisatellites with the length of the repeating unit of less than 25 nt, a shorter repeating motif can be distinguished in the sequence of this repeat, which often is similar to the sequence of minisatellites widely occurring in the human genome. A model of hierarchic origination of minisatellites in the human genome is suggested.
ISSN:0006-3029