Interaction of angiotensin II and III with adenosine A(1) receptor-related drugs in passive avoidance conditioning in rats

• Published in: Behavioural brain research Vol. 129; no. 1-2; pp. 61 - 64
• Main Authors: Tchekalarova, J, Kambourova, T, Georgiev, V
• Format: Journal Article
• Language: English
• Published: Netherlands 01.02.2002
• Subjects: Adenosine - analogs & derivatives; Adenosine - pharmacology; Angiotensin II - pharmacology; Angiotensin III - pharmacology; Animals; Avoidance Learning - drug effects; Dose-Response Relationship, Drug; Injections, Intraperitoneal; Injections, Intraventricular; Male; Memory - drug effects; Rats; Rats, Wistar; Receptors, Purinergic P1 - drug effects; Theophylline - pharmacology
• ISSN: 0166-4328
• DOI: 10.1016/S0166-4328(01)00319-9

The present study examines the functional interaction between angiotensins (ANG II and III) and adenosine A(1) receptor-related drugs on passive avoidance (step-through) conditioning in rats. ANG II and III were administered intracerebroventricularly (i.c.v.) while N(6)-cyclohexyladenosine (CHA) and theophylline-intraperitoneally (i.p.), immediately after the training trial. ANG II (0.1,0.5,1 microg) induced dose-dependent (inverted-U) increase of the retention while ANG III in the same doses decreased it upon re-testing of rats 24 h and 7 days later. The selective adenosine A(1) receptor agonist CHA (0.1 mg/kg) attenuated memory-enhancing effect of ANG II (0.1 microg) 24 h but not 7 days after the training session. Conversely, CHA had opposite i.e. facilitating effect on ANG III (0.1 microg) response upon re-testing 24 h and 7 days later. The pretreatment with ANG III attenuated the retention-improving effect exerted by the non-specific adenosine A(1)/A(2) receptor antagonist theophylline (75 mg/kg) 24 h and 7 days after the training trial. Taken together, the results show a mutual interaction of the drugs belonging to the adenosine and angiotensin modulatory systems in memory consolidation of rats.