Role of astrocytes activated by albumin in epileptogenesis

Epilepsy is one of the major neurological disorders characterized by spontaneous and recurrent seizures. Despite progress in the understanding of epilepsy, the exact network underlying the seizures is unclear. Actually the role of astrocytes in modulation of neuronal activity and the synaptic transm...

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Published inRevista de neurologiá Vol. 47; no. 11; pp. 582 - 587
Main Authors Herrera-Peco, I, Sola, R G, Osejo, V, Wix-Ramos, R, Pastor, J
Format Journal Article
LanguageSpanish
Published Spain 01.12.2008
Subjects
Albumins - metabolism
Astrocytes - cytology
Astrocytes - metabolism
Blood-Brain Barrier - anatomy & histology
Blood-Brain Barrier - physiology
Epilepsy - metabolism
Epilepsy - physiopathology
Humans
Neurons - cytology
Neurons - metabolism
Synapses - metabolism
Synaptic Transmission - physiology
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Summary:Epilepsy is one of the major neurological disorders characterized by spontaneous and recurrent seizures. Despite progress in the understanding of epilepsy, the exact network underlying the seizures is unclear. Actually the role of astrocytes in modulation of neuronal activity and the synaptic transmission is clear, making astrocytes as important players in processing of information in the central nervous system. These characteristics make us think that astrocytes have an important role in the epileptogenesis. Disruption of blood brain-barrier let the pass of albumin, and it could uptake into astrocytes. Numerous authors suggest that this can contribute to epileptogenesis. In view the data obtained from these factors (astrocytes and albumin), future studies will undoubted further to know its relation with epileptogenesis in humans and as therapeutics aims.
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ISSN:1576-6578
DOI:10.33588/rn.4711.2008583